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Gut mucosal virome alterations in ulcerative colitis

January 21, 2020

T Zuo, SH Wong, K Lam, R Lui, K Cheung, W Tang, JYL Ching, PKS Chan, MCW Chan, JCY Wu, FKL Chan, J Yu, JJY Sung, and SC Ng




We demonstrated for the first time that UC is characterised by substantial alterations of the mucosa virobiota with functional distortion. Enrichment of Caudovirales bacteriophages, increased phage/bacteria virulence functions and loss of viral-bacterial correlations in the UC mucosa highlight that mucosal virome may play an important role in UC pathogenesis.


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