Fecal Microbiota Transplantation

Our team is dedicated to the advancement of fecal microbiota transplantation (FMT) in Aisa. In addition to research, our FMT platform provide FMT services to both public and private patients.

What is FMT

FMT is a novel way to treat different diseases via infusion of special processed fecal solution from healthy donors to affected subjects

Publications

SC Ng, MA Kamm, YK Yeoh, PKS Chan, T Zuo, W Tang, A Sood, A Andoh, N Ohmiya, Y Zhou, CJ Ooi, V Mahachai, CY Wu, F Zhang, K Sugano, and FKL Chan, Scientific frontiers in faecal microbiota transplantation: joint document of Asia-Pacific Association of Gastroenterology (APAGE) and Asia-Pacific Society for Digestive Endoscopy (APSDE). Gut. 10, 2019 [IF: 17.973]

Full article: http://dx.doi.org/10.1136/gutjnl-2019-319407

CY Lai, J Sung, F Cheng, W Tang, SH Wong, PKS Chan, MA Kamm, JJY Sung, G Kaplan, FKL Chan, and SC Ng, Systematic review with meta-analysis: review of donor features, procedures and outcomes in 168 clinical studies of faecal microbiota transplantation. Aliment Pharmacol Ther. 02, 2019 [IF: 7.731]

Full article: https://doi.org/10.1111/apt.15116

T Zuo, SH Wong, CP Cheung, K Lam, R Lui, K Cheung, F Zhang, W Tang, JYL Ching, JCY Wu, PKS Chan, JJY Sung, J Yu, FKL Chan, and SC Ng, Gut fungal dysbiosis correlates with reduced efficacy of fecal microbiota transplantation in Clostridium difficile infection. Nature Communication. 09, 2018 [IF: 11.878]

Full article: https://doi.org/10.1038/s41467-018-06103-6

T Zuo, SH Wong, K Lam, R Lui, K Cheung, W Tang, JYL Ching, PKS Chan, MCW Chan, JCY Wu, FKL Chan, J Yu, JJY Sung, and SC Ng, Bacteriophage Transfer During Faecal Microbiota Transplantation in Clostridium Difficile Infection Is Associated with Treatment Outcome. Gut. 05, 2017. [IF: 17.973]

Full article: http://dx.doi.org/10.1136/gutjnl-2017-313952

Clinical Trials

Although fecal microbiota transplantation (FMT) is effective in treating patients with recurrent Clostridium difficile infection (CDI), the exact mechanism of FMT has been primarily ascribed to restoration of the gut bacterial microbiota. Our previous CDI study represents the first study to reveal that bacteriophage transfer is associated with FMT outcome and indicates that the restoration of virome community may be as important as that of the bacterial microbiome for FMT efficacy. Our team is working to extend the use of FMT to other diseases.

Clostridium Difficile

Stool Bank

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