CK Lee, SH Wong, G Lui, W Tang, LS Tam, M Ip, E Hung, MH Chen, JCY Wu, SC Ng Journal of Crohn's and Colitis Biologic therapies have revolutionised the treatment of immune-mediated diseases including inflammatory bowel disease [IBD] and rheumatological disorders. However, it is associated with an increased risk of reactivation of latent tuberculosis. In this study, we found that conversion of LTBI is common and occurred early during biologic therapy in an area with interm