H Shi, AN Levy, HD Trivedi, FKL Chan, SC Ng, and AN Ananthakrishnan, Clinical Gastroenterology and Hepatology. 06, 2017: p. Published Online First. [IF: 7.398]
Similarities and differences in disease presentation and outcomes across different geographic regions and ethnic groups have not been compared previously in inflammatory bowel disease (IBD). We performed a systematic review and meta-analysis of population based cohort studies examining the phenotype and outcome of IBD across ethnic groups, categorized as Whites, Blacks, Hispanics and Asians. Our final analysis included 198 unique studies reporting outcomes on 525,425 IBD patients. We demonstrate significant variation in the demographic distribution, familial predisposition, phenotype and outcomes of IBD between Caucasians, Blacks, Hispanics, and Asians. There is need for further study to understand the biology behind this variation.