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Accuracy of Fecal Immunochemical Test to Predict Endoscopic and Histological Healing in Ulcerative C

HY Shi, FKL Chan, AWH Chan, A Higashimori, M Kyaw, JYL Ching, AKC Luk, SH Wong, JCY Wu, JJY Sung, and SC Ng. Journal of Crohn's and Colitis. In Press, 2017. [IF: 5.813]

Endoscopic and histological healing are associated with improved clinical outcomes in ulcerative colitis [UC]. We measured quantitative faecal immunochemical test [FIT] and faecal calprotectin [FC] in 140 consecutive UC patients who underwent colonoscopy. We assessed the diagnostic accuracy of FIT for predicting endoscopic healing using the Mayo endoscopic subscore, and for histological healing using the Geboes score and Nancy index . The predictive abilities of FIT were compared with those of FC. FIT is highly sensitive and accurate to predict endoscopic and histological healing in UC. It represents a promising non-invasive tool for monitoring mucosal healing in UC.

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