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Cancer Risk in 2,621 Chinese Patients with Inflammatory Bowel Disease: A Population- Based Cohort St

J So, W Tang, WK Leung, M Li, FH Lo, TL Wong, SF Sze, CM Leung, WC Tsang, HS Shan, KH Chan, CY Lam, AJ Hui, WH Chow, TY Lam, V Lam, TW Lee, HH Lo, CM Tang, CL Wong, JCY Wu, FKL Chan, JJY Sung, M Harbord, and SC Ng, In Press, 2017. [IF: 4.525]

We conducted a population-based study to determine the risk of cancer in patients with Crohn's disease (CD) and ulcerative colitis (UC). We identified Two thousand six hundred twenty one patients with IBD (1108 CD; 1603 UC; median age, 49 yr; 59.5% men) and no history of cancer from 1990 to 2016. These patients were followed for 26,234 person-years. Eighty eight patients developed cancer after IBD diagnosis. Patients with CD had an increased risk of anorectal cancers and hematological cancers including leukemia. Nonmelanoma skin cancer was significantly increased in both CD and UC. Patients with CD had a higher risk of renal-cell carcinoma, and patients with UC had a higher risk of prostate cancer. In a population-based study, Chinese patients with CD are at an increased risk of anorectal cancers and hematological cancers compared with the general population. A higher risk of nonmelanoma skin cancer was also observed in CD and UC. Cancer surveillance should be considered.

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